Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression



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  • Prolonged fasting downregulates a IGF-1/PKA pathway in stem cells
  • Prolong fasting protects hematopoietic cells from chemotoxicity
  • Prolonged fasting cycles promote HSC self-renewal to reverse immunosuppression
  • Inhibition of IGF-1 or PKA signaling mimics the effects of prolonged fasting



Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration.



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Related:  Fasting triggers stem cell regeneration of damaged, old immune system


2 Responses to “Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression”

  1. Aleister of ATS said ” I’ve done a 14 hour fast every day (from my last food of the day until the first of the next) ever since I read in one of Swami Satchidananda’s books that the same organs we use to digest are the same organs that do toxic cleansing, and if we do a 14-hour fast then we have at least seven hours of toxic cleansing a day. As soon as I read that I started that routine, and haven’t missed a day. Good old Swami Satch.

    – See more at:

  2. Notes taken from posts by ATS members.

    “ I’ve thought about doing the strict intermittent fasting diet.
    It’s where you eat no more than 500 calories in 24 hours, every other day – then eat whatever you want every other day. On the fasting day, you eat very clean – no processed sugar or refined carbs.
    There was a study done that showed people who did this not only lost weight, but it eliminated or greatly improved existing conditions like type 2 diabetes, high blood pressure, heart disease, etc.
    The weird thing was, they had two different groups who either ate fairly healthy on their “eating” days, or ate really bad stuff like fried foods and sugary deserts. It didn’t matter. Both groups experienced the same benefits from the intermittent fasting.
    I would imagine it’s because you are essentially detoxing your system on the fasting day. “


    Hello all! I do Cell tower work, which involves climbing rigging and all sorts of fun stuff. The point is it’s a very demanding job physically and mentally.

    I also live a life style of Intermittent fasting, and for myself, IT WORKS!

    I eat from, noon to 8 pm each day, If i start eating at 1 pm, I end at 9 PM. During the last few hours of not eating, My mind and body feel faster, sharper, and very clear. Normally I have a meal at noon, and then another meal around 730 PM, with the potential for a snack somewhere in between. Water is a huge part of my fasting life. Also tea with no sugar gets me going in the morning. I have gone up to 24 hours of fasting, sometimes eating isn’t convenient with my work schedule.

    I rarely get sick, however the last time I took a break from Intermittent fasting, I had horrible bout with some food I ate, which i believe would not have happened had I been on my fasting.

    I have also found benefits from fasting such as consistent digestion, and bowel movements.

    If you have health issues I recommend it, I have seen in another close to me vast health improvements from fasting, and this person has a high rate of something always being and issue, including Staph and other frustrating illnesses, Which have yet to be explained by doctors.

    On a side note 16 hours no calories 8 hours eat all you want. I may try a 3 day fast, as not eating saves me money. Even when just on the normal schedule described above.

    Best of luck anyone who does try this, if you get a bit hormonal give it a week or two, and your body will sort itself out.

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