Linus Pauling’s Therapy

“Knowing that lysyl residues are what causes Lp(a) to stick to the wall of the artery and form atherosclerotic plaques, any physical chemist would say at once that to prevent that put the amino acid lysine in the blood to a greater extent than it is normally. – 92-year-old Linus Pauling

Last Updated: Thu Sep 18 12:43:10 EDT 2014

This web site was established in 1996 and is devoted to helping heart patients learn about the safe and apparently very effective treatment (even cure) for heart disease. The invention, by the great American scientist Linus Pauling and his German associate Matthias Rath, MD., is called the Pauling Therapy when utilized at the correct high dosages. — Owen Fonorow


No Prescription Required

“I think we can get almost complete control of cardiovascular disease, heart attacks and strokes by the proper use of (vitamin C and lysine) … even cure it.” From Linus Pauling’s Last Interview

Linus Pauling’s specific therapy for cardiovascular and heart diseases are high dosages of two essential nutrients; vitamin C and the amino acid lysine.

Vitamin C is required to strengthen arteries so that the body does not try to patch arteries with “plaster casts” (atherosclerosis).

Lysine is an Lp(a) binding inhibitor, meaning at sufficient dosage it can reverse the plaster cast build-up (atherosclerotic plaques.) Lp(a) is the sticky form of LDL cholesterol that Pauling/Rath identified as the primary risk factor.

Testimonials abound, yet medicine continues to ignore the science and growing evidence. As far as modern medicine is concerned, the material presented here doesn’t exist.

We agree with Pauling that two harmless substances together can treat and cure heart disease is indeed miraculous. Both substances are essential foods, meaning they are both required for life (in smaller amounts. They are extremely safe in high amounts, neither has a known lethal toxic dosage.)

There is a Slight Problem . . .

The reason your doctor has never heard about this from trusted sources is because this low-cost therapy would bankrupt every major hospital in the USA.

“Did you know that bypass surgery (in which a blocked coronary artery is replaced by a clean artery obtained from the thigh) is one of the biggest growth industries in the United States? Would it surprise you to learn that this procedure brings in more money to metropolitan hospitals than does any other type of care? In many cases bypass surgery accounts for 30 to 40 percent of a hospital’s total income.” – Stephen Cherniske (DHEA Breakthrough, 1996)


The Unified Theory

Linus Pauling and Matthias Rath alerted the world to the cause of heart disease in 1989 — a chronic, sub-clinical vitamin C deficiency — due to a missing liver enzyme caused by the ancient GULO genetic defect in primate DNA. [1]

Pauling, the founder of modern chemistry, holder of 48 honorary Ph.D.s, and the world’s only 2-time unshared Nobel prize laureate, theorized that too little vitamin C elevates cholesterol levels, including the Lp(a) variant that causes narrowing of blood vessels. After Pauling learned that Lp(a) binds to strands of lysine protruding from weak and damaged blood vessels, he invented the high-lysine therapy described here.

“Knowing that lysyl residues are what causes Lp(a) to stick to the wall of the artery and form atherosclerotic plaques, any physical chemist would say at once that to prevent that put the amino acid lysine in the blood to a greater extent than it is normally. – 92-year-old Linus Pauling

His specific high-dosage therapy for heart disease is apparently very effective, and it has been named the Pauling Therapy in Linus’s honor.

The Pauling/Rath unified (vitamin C) theory of cardiovascular disease constitutes one of the great potential breakthroughs of modern science. Their remarkable theory, and its intriguing claim that very low cost Lp(a) binding inhibitors will prevent and even dissolve arterial blockages has apparently gone unnoticed by the pharmaceutical industry, the medical profession and the media. [2]

The ‘banned’ Pauling/Rath Unified Theory Paper (PDF)

Note: This paper was first accepted by the Proceedings of the National Academy of Sciences USA, but then rejected and not published.

“Its Almost Miraculous” – Linus Pauling

It would be a miracle if the cure for heart disease already exists. It would be even more miraculous if the therapy that leads to the cure works quickly, (even in advanced disease), is completely non toxic, inexpensive, and if it is available at any drug store without a prescription!

When your doctor tells you that this theory “hasn’t been proven,” you should know that it hasn’t been studied. Incredibly this outstanding achievement by one or most outstanding scientists has been ignored. Should your doctor tell you the therapy is unproven, you can retort that no one has proven that it doesn’t work. Or, like many people before you, you can say nothing to your doctor and let him or her think their treatments somehow worked. — Owen Fonorow

We owe a deep debt of gratitude for this miracle to America’s greatest scientist, the late Linus Pauling, Ph.D., and his German associate Matthias Rath, MD.

Pauling/Rath Patents

Can It Really Be So Simple?

Briefly, researchers discovered cholesterol lysine-binding-sites that lead to heart disease. [4] [5] [6] [7] Medical doctors have heard about the “lysine binding sites”, but they aren’t told that these receptors are ONLY found on one form of cholesterol; a sticky form of LDL cholestrol called Lp(a).

This discovery was verified in humang beings in 1989. A German team led by Beisiegel discovered that only Lp(a) was inside the clogged aortas of those who had died of heart disease. They did not find any ordinary LDL (bad) cholesterol [8] in these arteries near the heart. (Matthias Rath, then a medical student, was on the team. He made the probable connection between Lp(a) and vitamin C and brought this news and idea to the attention of Linus Pauling.)


Upon hearing of this discovery, Pauling invented the heart disease therapy presented here.

Rationale: If Lp(a) causes heart disease, and if Lp(a) attaches to the artery at the lysine binding sites, then the solution is apparent: Give Lp(a) in the blood something else to attach to.

Linus Pauling’s brilliant invention (and now therapy named in his honor) increases the blood concentration of vitamin C and of lysine to neutralize the Lp(a).

“I recommend that every person who is at risk of heart disease should take 5 or 6 g of vitamin C and at least 2 g of lysine, although larger amounts may be necessary.” – Linus Pauling

Lp(a) and the Lysine Binding Sites

“Many investigators contributed to demonstrating that it is lipoprotein(a) that is deposited in plaques, not merely LDL, but lipoprotein(a), or Lp(a) for short. If you have more than 20 mg/dl in the blood it begins to deposit plaques and causes atherosclerosis. The question then is: What causes Lp(a) to stick to the wall of the artery and form these plaques?

“Countless biochemists and chemists discovered what in the wall of the artery causes Lp(a) to adhere and form atherosclerotic plaques and ultimately lead to heart disease, strokes, and peripheral arterial disease. The answer is that there is a particular amino acid in a protein in the wall of the artery – lysine – which is one of the twenty amino acids that binds the Lp(a) and causes atherosclerotic plaques to develop. I THINK IT IS A VERY IMPORTANT DISCOVERY”

“Knowing that lysyl residues are what causes Lp(a) to stick to the wall of the artery and form atherosclerotic plaques, any physical chemist would say at once that to prevent that put the amino acid lysine in the blood to a greater extent than it is normally. You need lysine, it is essential, you have to get about 1 gram a day to keep in protein balance, but we can take lysine, pure lysine, a perfectly non toxic substance as supplements, which puts extra lysine molecules in the blood. They enter into competition with the lysyl residues on the wall of arteries and accordingly count to prevent Lp(a) from being deposited, or even will work to pull it loose and destroy atherosclerotic plaques.”

– Linus Pauling (From the Linus Pauling Video on Heart Disease, 1992)

Subequently, researchers at the University of Chicago discovered the proline-binding-site on Lp(a).[9]


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