At the Institute for Regenerative Medicine in Pittsburgh, fast-aging elderly mice with a usual lifespan of approximately 21 days were injected with stem cells from younger mice. They were given the injection approximately four days before they were expected to die, and the results were outstanding. Mice who were injected not only lived, but they live 3 times their normal lifespan, surviving for an additional 71 days. In human terms, that would be the equivalent of an 80-year old living to be 200 years old.
The research was published in Nature Communications, by Mitra Lavasani in 2012. The mice were genetically engineered to be fast-aging.
“Specifically, the investigators studied the effects of injecting muscle-derived stem/progenitor cells (MDSPCs) into a murine progeria model (fast-aging mice). Since age-related degenerative changes are universal in the musculoskeletal system, the impact on the musculoskeletal system by murine muscle-derived stem/progenitor cells (MDSPCs) became the primary focus of the experiments. MDSPCs are multipotent cells isolated from postnatal skeletal muscle. They have the capacity for long-term proliferation, are resistant to oxidative and inflammatory stress, show multilineage differentiation and self-renew, induce neovascularization, and stimulate regeneration of bone, skeletal, and cardiac muscles. These characteristics raise the possibility that the loss of MDSPCs or related perivascular progenitor cells could contribute to sarcopenia, osteoporosis and other age-associated degenerative diseases.”
This is a significant finding, it could not only extend the life of humans but also be able to delay symptoms that are correlated with aging.